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中國精品科技期刊2020

基于熵權-層次分析法及反向傳播神經網絡多指標優化地黃水提物提取工藝

祝子喻 謝雨欣 俞月婷 張梅

祝子喻,謝雨欣,俞月婷,等. 基于熵權-層次分析法及反向傳播神經網絡多指標優化地黃水提物提取工藝[J]. 食品工業科技,2022,43(19):264?272. doi:  10.13386/j.issn1002-0306.2021120331
引用本文: 祝子喻,謝雨欣,俞月婷,等. 基于熵權-層次分析法及反向傳播神經網絡多指標優化地黃水提物提取工藝[J]. 食品工業科技,2022,43(19):264?272. doi:  10.13386/j.issn1002-0306.2021120331
ZHU Ziyu, XIE Yuxin, YU Yueting, et al. Optimization of Extraction Process of Aqueous Extract of Rehmannia glutinosa Based on Entropy Weight Method in Cooperation with Analytic Hierarchy Process and Back Propagation Neural Network with Multiple Indicators[J]. Science and Technology of Food Industry, 2022, 43(19): 264?272. (in Chinese with English abstract). doi:  10.13386/j.issn1002-0306.2021120331
Citation: ZHU Ziyu, XIE Yuxin, YU Yueting, et al. Optimization of Extraction Process of Aqueous Extract of Rehmannia glutinosa Based on Entropy Weight Method in Cooperation with Analytic Hierarchy Process and Back Propagation Neural Network with Multiple Indicators[J]. Science and Technology of Food Industry, 2022, 43(19): 264?272. (in Chinese with English abstract). doi:  10.13386/j.issn1002-0306.2021120331

基于熵權-層次分析法及反向傳播神經網絡多指標優化地黃水提物提取工藝

doi: 10.13386/j.issn1002-0306.2021120331
基金項目: 國家自然科學基金(82174273)。
詳細信息
    作者簡介:

    祝子喻(1997?),女,碩士研究生,研究方向:中藥物質基礎及質量評價研究,E-mail:zhuziyu@stu.cdutcm.edu.cn

    通訊作者:

    張梅(1963?),女,博士,教授,研究方向:中藥物質基礎及質量評價研究,E-mail:zhangmei63@126.com

  • 中圖分類號: R284.2

Optimization of Extraction Process of Aqueous Extract of Rehmannia glutinosa Based on Entropy Weight Method in Cooperation with Analytic Hierarchy Process and Back Propagation Neural Network with Multiple Indicators

  • 摘要: 目的:基于熵權法(Entropy Weight Method, EWM)-層次分析(Analytic Hierarchy Process, AHP)和反向傳播神經網絡(Back Propagation Neural Network, BPNN)對地黃水提物超聲提取工藝進行優化。方法:以超聲溫度、超聲時間、料液比為正交試驗考察因素,梓醇、地黃苷D、益母草苷,地黃多糖含量以及水溶性浸出物得率為指標,采用EWM-AHP法確定各指標權重,從而得到多指標綜合得分;再以正交試驗工藝條件為輸入,綜合得分為輸出,建立并訓練BPNN模型,尋找地黃提取最佳工藝。結果:BPNN優選工藝為在60 ℃下,加33倍水,提取70 min,梓醇、地黃苷D、益母草苷,地黃多糖含量以及水溶性浸出物得率平均值分別為17.04 、3.75、10.57、24.86 mg/g 、0.82 g/g,綜合得分為97.74;正交試驗最佳工藝為提取溫度50 ℃,加25倍水,提取1 h,梓醇、地黃苷D、益母草苷,地黃多糖含量以及水溶性浸出物得率平均值分別為12.72、2.58、8.20、25.02 mg/g、0.80 g/g,綜合得分為97.26。結論:本研究確定BPNN優選工藝為最優,為EWM-AHP法結合BPNN在提取工藝中的應用提供了參考。
  • 圖  1  地黃供試品溶液(A)與混合對照品溶液(B)HPLC色譜圖

    Figure  1.  HPLC chromatograms of test solution (A) and mixed reference solution (B) of Rehmannia glutinosa

    注:1.梓醇;2.地黃苷D;3.益母草苷。

    圖  2  單因素實驗結果

    Figure  2.  Results of single factor study

    圖  3  BPNN結構示意圖

    Figure  3.  Schematic diagram of BPNN structure

    圖  4  BPNN均方差

    Figure  4.  Mean square error of BPNN

    圖  5  BPNN可靠性驗證

    Figure  5.  Reliability verification of BPNN

    表  1  地黃提取工藝正交試驗因素水平

    Table  1.   Factors level of orthogonal test of Rehmannia glutinosa extraction process

    水平提取溫度(℃)提取時間(h)料液比(g/mL)
    ABC
    1500.51:25
    2551.01:50
    3601.51:100
    下載: 導出CSV

    表  2  指標成對比較的判斷優先矩陣

    Table  2.   Judgment precedence matrix for paired comparison of indicators

    指標成分梓醇地黃苷D地黃多糖益母草苷水溶性浸出物
    梓醇12134
    地黃苷D1/211/223
    地黃多糖12134
    益母草苷1/31/21/312
    水溶性浸出物1/41/31/41/21
    下載: 導出CSV

    表  3  線性關系考察結果

    Table  3.   Linear relationship examination results

    成分回歸方程相關系數(R線性范圍(mg/mL)
    梓醇Y=8903.4X+9E?130.99980.034~1.047
    地黃苷DY=5877.5X+3.63830.99970.037~1.141
    益母草苷Y=1299.9X+1.57411.00000.048~1.390
    多糖Y = 0.014X+0.00730.99950.005096~0.05960
    下載: 導出CSV

    表  4  精密度、重復性、穩定性和加樣回收率結果

    Table  4.   Precision, repeatability, stability and recovery results

    指標性成分精密度 重復性 穩定性 加樣回收率
    RSD
    (%)
    含量
    (mg/g)
    RSD
    (%)
    RSD
    (%)
    平均加樣回
    收率(%)
    RSD
    (%)
    梓醇0.02 10.681.20 1.36 95.981.09
    地黃苷D0.742.2171.561.33102.041.49
    益母草苷0.477.6392.002.0898.693.84
    地黃多糖0.0826.620.791.40102.362.19
    下載: 導出CSV

    表  5  地黃提取工藝L9(34)正交試驗結果

    Table  5.   Orthogonal test results of extraction technology L9(34) of Rehmannia glutinosa

    實驗號ABCD梓醇
    (mg/g)
    地黃苷D
    (mg/g)
    益母草苷
    (mg/g)
    地黃多糖
    (mg/g)
    水溶性浸
    出物(g/g)
    1111111.842.947.4921.880.8117
    2122212.192.417.2718.800.8456
    3133312.682.347.2513.480.8716
    4212312.062.377.3817.560.8412
    5223112.732.407.3016.890.8347
    6231211.872.347.2422.870.8143
    7313212.152.427.0313.660.8535
    8321311.822.367.5624.770.8271
    9332111.962.367.1624.970.8201
    下載: 導出CSV

    表  6  EWM、AHP、EWM-AHP法權重系數

    Table  6.   EWM, AHP and EWM-AHP weight coefficient

    方法權重系數
    梓醇多糖地黃苷D益母草苷水溶性浸出物
    EWM法0.21820.13800.40590.08890.1490
    AHP法0.31860.31860.18410.11000.0687
    EWM-AHP法0.33390.21110.35890.04700.0492
    下載: 導出CSV

    表  7  EWM -AHP法復合評分的正交結果

    Table  7.   Orthogonal results of EWM-AHP composite scoring method

    分析
    方法
    實驗號ABCDEWM
    法綜合
    評分
    AHP
    法綜合
    評分
    EWM-
    AHP復
    合評分
    1111195.7593.3694.71
    2122287.6586.9186.62
    3133384.9581.0582.64
    4212386.0784.7784.65
    5223186.9985.5886.06
    6231287.5290.3887.93
    7313284.3679.7981.89
    8321389.1793.2689.78
    9332188.9793.2390.06
    EWM
    法綜合
    評分
    K1268.34266.18272.44271.70
    K2260.58263.81262.68259.53
    K3262.50261.44256.30260.20
    R7.774.7416.1412.17
    AHP法
    綜合
    評分
    K1261.31257.92276.99272.16
    K2260.73265.74264.92257.08
    K3266.28264.65246.41259.07
    R5.557.8230.5815.09
    EWM-AHP
    復合
    評分
    K1263.98261.26272.43270.84
    K2258.65262.46261.33256.45
    K3261.73260.64250.60257.07
    R5.331.8221.8314.39
    下載: 導出CSV

    表  8  方差分析

    Table  8.   Analysis of variance

    分析方法方差來源離差平方和自由度F
    EWM綜合評分A26.398020.51100.6620
    B34.836020.67400.5970
    C291.783025.64800.1500
    D(誤差)51.65802??
    AHP法綜合評分A7.598020.17000.8550
    B12.620020.28300.7800
    C158.160023.54300.2200
    D(誤差)44.63402??
    EWM-AHP復合評分法A5.077020.10800.9020
    B0.521020.01100.9890
    C81.812021.74100.3650
    D(誤差)46.98802??
    下載: 導出CSV

    表  9  BPNN預測數據

    Table  9.   Prediction data of BPNN

    序號超聲溫度(℃)時間(min)料液比分數序號超聲溫度(℃)時間(min)料液比分數
    150700.0481.814355400.0289.85
    250700.0381.824460900.0490.06
    360300.0281.894560700.0190.49
    450600.0381.984655500.0490.60
    550900.0182.644760400.0490.84
    650600.0482.824860600.0291.37
    750900.0283.424960800.0191.41
    850800.0483.535055500.0191.49
    955300.0183.625155300.0391.52
    1050800.0283.795250400.0391.55
    1150800.0383.995350400.0291.65
    1250800.0184.055455800.0191.69
    1355700.0484.555550600.0191.74
    1460300.0184.565660900.0191.78
    1550700.0284.795750500.0191.87
    1650900.0384.885860500.0392.03
    1760400.0284.955955400.0392.09
    1850500.0485.406060500.0492.18
    1955800.0485.786150300.0292.38
    2055900.0485.906255700.0392.39
    2160300.0386.086355400.0492.46
    2250500.0386.326455500.0392.64
    2355900.0386.376555300.0492.83
    2450600.0286.626660700.0292.87
    2550900.0486.676760900.0292.91
    2655600.0486.706855800.0293.08
    2755900.0186.906955600.0193.22
    2855400.0187.407055700.0193.41
    2955300.0287.537155600.0393.46
    3050700.0187.767260800.0293.53
    3160400.0187.907355500.0293.69
    3255900.0287.937450300.0394.41
    3360400.0387.967560600.0494.53
    3450300.0188.167660900.0394.64
    3560500.0288.947760800.0494.68
    3655800.0388.967850300.0494.71
    3760500.0189.247960600.0396.75
    3850500.0289.468060700.0496.82
    3950400.0189.628155700.0297.13
    4060300.0489.688255600.0297.29
    4150400.0489.758360800.0398.10
    4260600.0189.788460700.0398.69
    下載: 導出CSV

    表  10  工藝驗證結果($\bar {\rm{x}} $±s, n=3)

    Table  10.   Process verification results ($\bar {\rm{x}} $±s, n=3)

    分組梓醇(mg/g)地黃多糖(mg/g)地黃苷D(mg/g)益母草苷(mg/g)水溶性浸出物(g/g)復合評分均值
    BPNN最佳工藝17.04±0.1024.86±2.543.75±0.1510.57±0.860.82±0.005897.74
    正交最優工藝12.72±0.3025.02±0.492.58±0.048.20±0.360.80±0.005897.26
    下載: 導出CSV
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  • [1] 張維方, 樊克鋒, 雷敬衛, 等. 地黃藥材的紅外指紋圖譜及多元統計分析[J]. 光譜學與光譜分析,2021,41(11):3392?3398. [ZHANG W F, FAN K F, LEI J W, et al. Infrared fingerprint and multivariate statistical analysis of Rehmannia glutinosa[J]. Spectroscopy and Spectral Analysis,2021,41(11):3392?3398.

    ZHANG W F, FAN K F, LEl J W, et al. Infrared fingerprint and multivariate statistical analysis of Rehmannia glutinosa[J]. Spectroscopy and Spectral Analysis, 2021, 41(11): 3392-3398.
    [2] THU V K, THOA N T, HIEN N T T, et al. Iridoid glycosides link with phenylpropanoids from Rehmannia glutinosa[J]. Natural Product Research,2021(5):1?6.
    [3] 徐卓, 戴新新, 宿樹蘭, 等. 基于UPLC-TQ-MS的地黃中核苷類和氨基酸類成分動態積累研究[J]. 中草藥,2021,52(23):7323?7330. [XU Z, DAI X X, XIU S L, et al. Analysis of dynamic accumulation of nucleosides and amino acids in Rehmannia glutinosa based on UPLC-TQ-MS[J]. Chinese Traditional and Herbal Drug,2021,52(23):7323?7330. doi:  10.7501/j.issn.0253-2670.2021.23.027

    XU Z, DAI X X, XIU S L, et al. Analysis of dynamic accumulation of nucleosides and amino acids in Rehmannia glutinosa based on UPLC-TQ-MS[J]. Chinese Traditional and Herbal Drug, 2021, 52(23): 7323-7330. doi:  10.7501/j.issn.0253-2670.2021.23.027
    [4] 汪程遠, 張浩, 孟莉, 等. 大孔吸附樹脂分離純化生地黃中苷類與糖類[J]. 中藥材,2003(3):202?204. [WANG C Y, SUN H, MENG L, et al. Separation and purification of polysaccharides from Rehmannia glutinosa by macroporous adsorption resin[J]. Journal of Chinese Medicinal Materials,2003(3):202?204. doi:  10.3321/j.issn:1001-4454.2003.03.022

    WANG C Y, SUN H, MENG L, et al. Separation and purification of polysaccharides from Rehmannia glutinosa by macroporous adsorption resin[J]. Journal of Chinese Medicinal Materials, 2003(3): 202-204. doi:  10.3321/j.issn:1001-4454.2003.03.022
    [5] 陳金鵬, 張克霞, 劉毅, 等. 地黃化學成分和藥理作用的研究進展[J]. 中草藥,2021(6):1772?1784. [CHEN J P, ZHANG K X, LIU Y, et al. Research progress on chemical constituents and pharmacological actions of Rehmannia glutinosa[J]. Chinese Traditional and Herbal Drug,2021(6):1772?1784. doi:  10.7501/j.issn.0253-2670.2021.06.028

    CHEN J P, ZHANG K X, LIU Y, et al. Research progress on chemical constituents and pharmacological actions of Rehmannia glutinosa[J]. Chinese Traditional and Herbal Drug, 2021(6): 1772-1784. doi:  10.7501/j.issn.0253-2670.2021.06.028
    [6] JO R, MIN J R, JEONG S H. Anti-diabetic effects of water extracts of Rehmannia glutinosa Libosch root in 3T3-L1 adipocytes and C57BL/KsJ-db/db mice[J]. Journal of the Korean Society of Food Science and Nutrition,2018,47(10):957?965. doi:  10.3746/jkfn.2018.47.10.957
    [7] TSENG Y T, CHANG W H, LIN C C, et al. Protective effects of Liuwei dihuang water extracts on diabetic muscle atrophy[J]. Phytomedicine, 2018, 53: 96-106.
    [8] ZHOU X D, SHI D D, ZHANG Z J, et al. Ameliorative effects of Radix rehmanniae extract on the anxiety and depression like symptoms in ovariectomized mice: A behavioral and molecular study[J]. Phytomedicine,2019,63:153012. doi:  10.1016/j.phymed.2019.153012
    [9] GONG W, ZHANG N D, CHENG G, et al. Rehmannia glutinosa Libosch extracts prevent bone loss and architectural deterioration and enhance osteoblastic bone formation by regulating the IGF-1/PI3K/mTOR pathway in streptozotocin-induced diabetic rats[J]. International Journal of Molecular Sciences,2019,20(16):3964. doi:  10.3390/ijms20163964
    [10] 曹瑞, 張紅, 師延瓊, 等. 響應面法分析優化生地黃提取工藝研究[J]. 醫學研究雜志,2014,43(2):69?72. [CAO R, ZHANG H, SHI Y Q, et al. Optimization of extraction technology of Rehmannia glutinosa by response surface methodology[J]. Journal of Medical Research,2014,43(2):69?72.

    CAO R, ZHANG H, SHI Y Q, et al. Optimization of extraction technology of Rehmannia glutinosa by response surface methodology[J]. Journal of Medical Research, 2014, 43(2): 69-72.
    [11] 熊輝, 朱軍, 陳琴華. 地黃不同提取工藝中梓醇含量的比較[J]. 中國醫院藥學雜志,2015,35(17):1610?1612. [XIONG H, ZHU J, CHEN Q H. Comparison of contents of catalpol in Radix Rehmanniae by different extraction methods[J]. Chinese Journal of Hospital Pharmacy,2015,35(17):1610?1612. doi:  10.13286/j.cnki.chinhosppharmacyj.2015.17.21

    XIONG H, ZHU J, CHEN Q H. Comparison of contents of catalpol in Radix Rehmanniae by different extraction methods[J]. Chinese Journal of Hospital Pharmacy, 2015, 35(17): 1610-1612. doi:  10.13286/j.cnki.chinhosppharmacyj.2015.17.21
    [12] 王慧森, 劉明, 李更生, 等. 鮮地黃提取物中3種原型入血成分的含量測定[J]. 中國實驗方劑學雜志,2013,19(12):66?70. [WANG H S, LIU M, LI G S, et al. Determination for three prototype constituents into the blood from extract of fresh Rehmannia qlutinosa[J]. Chinese Journal of Experimental Traditional Medical Formulae,2013,19(12):66?70.

    [WANG H S, LIU M, LI G S, et al. Determination for three prototype constituents into the blood from extract of fresh Rehmannia qlutinosa[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2013, 19(12): 66-70].
    [13] BHATTAMISRA S K, KOH H M, LIM S Y, et al. Molecular and biochemical pathways of catalpol in alleviating diabetes mellitus and its complications[J]. Biomolecules,2021,11(2):27.
    [14] BI J J, LI J, CHEN S J, et al. Catalpol ameliorates type II collagen-induced arthritis in rats and inhibits LPS-stimulated inflammatory response in SW982 human synovial cells[J]. Journal of Functional Foods,2019,59:291?300. doi:  10.1016/j.jff.2019.05.050
    [15] 田平平, 潘穎, 施維, 等. 地黃中益母草苷對食管癌細胞增殖抑制作用的研究[J]. 園藝與種苗,2021,41(10):13?15,17. [TIAN P P, PAN Y, SHI W, et al. Inhibitory effect of ajugol in Rehmannia qlutinosa on the proliferation of esophageal carcinoma cells[J]. Horticulture & Seed,2021,41(10):13?15,17.

    TIAN P P, PAN Y, SHI W, et al. Inhibitory effect of ajugol in Rehmannia qlutinosa on the proliferation of esophageal carcinoma cells[J]. Horticulture & Seed, 2021, 41(10): 13-15, 17.
    [16] ZHOU J, XU G, YAN J Y, et al. Rehmannia glutinosa (Gaertn. ) DC. polysaccharide ameliorates hyperglycemia, hyperlipemia and vascular inflammation in streptozotocin-induced diabetic mice[J]. Journal of Ethnopharmacology,2015,164:229?238. doi:  10.1016/j.jep.2015.02.026
    [17] 高帥, 泮思林, 杜占慧, 等. 地黃多糖抑制大鼠主動脈血管鈣化的實驗研究[J]. 中華實驗外科雜志,2021(8):1466?1469. [GAO S, PAN S L, DU Z H, et al. Inhibitory effect of Rehmannia glutinosa polysaccharide on aortic calcification in rats[J]. Chinese Journal of Experimental Surgery,2021(8):1466?1469. doi:  10.3760/cma.j.cn421213-20210116-00057

    GAO S, PAN S L, DU Z H, et al. Inhibitory effect of Rehmannia glutinosa polysaccharide on aortic calcification in rats[J]. Chinese Journal of Experimental Surgery, 2021(8): 1466-1469. doi:  10.3760/cma.j.cn421213-20210116-00057
    [18] 潘小紅, 李濤, 殷帥, 等. 超聲波輔助提取對地黃中藥材及成方制劑含量測定的影響[J]. 中醫藥導報,2020,26(8):12?15,23. [PAN X H, LI T, YIN S, et al. Effect of ultrasonic-assisted extraction on the content determination of dihuang (Radix Rehmanniae) and its preparations[J]. Guiding Journal of Traditional Chinese Medicine and Pharmacy,2020,26(8):12?15,23.

    PAN X H, LI T, YIN S, et al. Effect of ultrasonic-assisted extraction on the content determination of dihuang (Radix Rehmanniae) and its preparations[J]. Guiding Journal of Traditional Chinese Medicine and Pharmacy, 2020, 26(8): 12-15, 23.
    [19] 張紅果, 張汝學, 賈正平, 等. 正交實驗法優選地黃寡糖有效部位的提取工藝[J]. 中國實驗方劑學雜志,2010,16(5):27?29. [ZHANG H G, ZHANG R X, JIA Z P, et al. Orthogonal experiment was used to optimize the extraction process of oligosaccharide from Rehmannia glutinosa[J]. Chinese Journal of Experimental Traditional Medical Formulae,2010,16(5):27?29. doi:  10.3969/j.issn.1005-9903.2010.05.007

    ZHANG H G, ZHANG R X, JIA Z P, et al. Orthogonal experiment was used to optimize the extraction process of oligosaccharide from Rehmannia glutinosa[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2010, 16(5): 27-29. doi:  10.3969/j.issn.1005-9903.2010.05.007
    [20] 尤游, 張林靜. 基于組合賦權和BPNN的高校學生綜合素質評價研究[J]. 安徽電子信息職業技術學院學報,2021,20(5):5?9. [YOU Y, ZHANG L J. Research on comprehensive quality evaluation of college students based on combined weight and BP neural network[J]. Journal of Anhui Yocatlonal College of Electronic& Information Technology,2021,20(5):5?9. doi:  10.3969/j.issn.1671-802X.2021.05.002

    YOU Y, ZHANG L J. Research on comprehensive quality evaluation of college students based on combined weight and BP neural network[J]. Journal of Anhui Yocatlonal College of Electronic& Information Technology, 2021, 20(5): 5-9. doi:  10.3969/j.issn.1671-802X.2021.05.002
    [21] 黃露, 徐頂巧, 樂世俊, 等. 基于層次分析-熵權法和網絡藥理學的野馬追質量標志物研究[J]. 中國中藥雜志,2021,46(21):5545?5554. [HUANG L, XU D Q, LE S J, et al. Research on Q-markers of Eupatorium lindleyanum based on analytic hierarchy process-entropy weight method and network pharmacology[J]. China Journal of Chinese Materia Medica,2021,46(21):5545?5554.

    HUANG L, XU D Q, LE S J, et al. Research on Q-markers of Eupatorium lindleyanum based on analytic hierarchy process-entropy weight method and network pharmacology[J]. China Journal of Chinese Materia Medica, 2021, 46(21): 5545-5554.
    [22] 謝平, 魏海峰, 溫仁華, 等. 基于BPNN-遺傳算法和信息熵理論優化涼粉草煎煮提取工藝[J]. 中國中醫藥信息雜志,2021,29(2):86?92. [XIE P, WEI H F, WEN R H, et al. Optimization on extraction process of Mesona chinensis Benth. based on BP neural network genetic algorithm and information entropy theory[J]. Chinese Journal of Information on TCM,2021,29(2):86?92.

    XIE P, WEI H F, WEN R H, et al. Optimization on extraction process of Mesona chinensis Benth. based on BP neural network genetic algorithm and information entropy theory[J]. Chinese Journal of Information on TCM, 2021, 29(2): 86-92.
    [23] 張曉萍, 張建民. 基于BPNN的復合型挑坎體型參數反演研究[J]. 水利水電技術(中英文),2021,53(4):138?147. [ZHANG X P, ZHANG J M. Study on shape parameter inversion of compound bucket based on BP neural network[J]. Water Resources and Hydropower Engineering,2021,53(4):138?147.

    ZHANG X P, ZHANG J M. Study on shape parameter inversion of compound bucket based on BP neural network[J]. Water Resources and Hydropower Engineering, 2021, 53(4): 138-147.
    [24] 張留記, 王建霞, 屠萬倩, 等. 生地黃與熟地黃中5個苷類成分和總多糖的含量比較[J]. 天然產物研究與開發,2019,31(4):566?571. [ZHANG L J, WANG J X, TU W Q, et al. Comparation of the contents of 5 glycosides and total polysaccharides in Rehmanniae Radix and Rehmanniae Radix Praeparata[J]. Natural Product Research and Development,2019,31(4):566?571.

    ZHANG L J, WANG J X, TU W Q, et al. Comparation of the contents of 5 glycosides and total polysaccharides in Rehmanniae Radix and Rehmanniae Radix Praeparata[J]. Natural Product Research and Development, 2019, 31(4): 566-571.
    [25] 張駱琪, 劉蘇偉, 王飛, 等. 地黃多糖超聲提取工藝優化及其抗氧化活性[J]. 中成藥,2018,40(12):2662?2667. [ZHANG L Q, LIU S W, WANG F, et al. Polysaccharides from Rehmannia glutinosa, their ultrasonic extraction process optimization and antioxidant activity[J]. Chinese Traditional Patent Medicine,2018,40(12):2662?2667. doi:  10.3969/j.issn.1001-1528.2018.12.010

    ZHANG L Q, LIU S W, WANG F, et al. Polysaccharides from Rehmannia glutinosa, their ultrasonic extraction process optimization and antioxidant activity[J]. Chinese Traditional Patent Medicine, 2018, 40(12): 2662-2667. doi:  10.3969/j.issn.1001-1528.2018.12.010
    [26] 扈本荃, 徐玥, 吳曼, 等. 地黃飲超聲提取工藝的研究[J]. 化學工程師,2021,35(12):71?73,19. [HU B Q, XU Y, WU M, et al. Study on the medthod for ultrasonic extraction of Dihuang Yin by orthogonal experiment[J]. Chemical Engineer,2021,35(12):71?73,19.

    HU B Q, XU Y, WU M, et al. Study on the medthod for ultrasonic extraction of Dihuang Yin by orthogonal experiment[J]. Chemical Engineer, 2021, 35(12): 71-73, 19.
    [27] 祁小妮, 林楠楠, 李振亮, 等. 生地黃多糖提取工藝的優化及抗氧化活性研究[J]. 食品與發酵工業,2016,42(2):231?235. [QI X N, LIN N N, LI Z L, et al. Optimization of Rehmannia glutinosa polysaccharide extraction process and antioxidant activity study[J]. Food and Fermentation Industries,2016,42(2):231?235.

    QI X N, LIN N N, LI Z L, et al. Optimization of Rehmannia glutinosa polysaccharide extraction process and antioxidant activity study[J]. Food and Fermentation Industries, 2016, 42(2): 231-235.
    [28] 國家藥典委員會. 中華人民共和國藥典. 四部[S]. 北京: 中國醫藥科技出版社, 2020.

    National Pharmacopoeia Commission. Pharmacopoeia of the People’s Republic of China. Four Parts[S]. Beijing: China Pharmaceutical Science and Technology Press, 2020.
    [29] 劉路路, 李可, 韋智江, 等. 基于響應面法和熵權法優化連翹葉中連翹酯A、連翹苷和蘆丁提取工藝[J]. 食品工業科技,2022,43(2):166?173. [LIU L L, LI K, WEI Z J, et al. Optimization of extraction process of forsythioside A, forsythin and rutin from Forsythia suspensa leaves based on response surface methodology and entropy weight method[J]. Science and Technology of Food Industry,2022,43(2):166?173.

    LIU L L, LI K, WEI Z J, et al. Optimization of extraction process of forsythioside A, forsythin and rutin from Forsythia suspensa leaves based on response surface methodology and entropy weight method[J]. Science and Technology of Food Industry, 2022, 43(2): 166-173.
    [30] 錢怡潔, 皮文霞, 朱廣飛, 等. 基于熵權法結合層次分析法和反向傳播神經網絡優選酒萸肉蒸制工藝[J]. 中草藥,2021,52(22):6816?6824. [QIAN Y J, PI W X, ZHU G F, et al. Optimization of processing technology of wine-steamed Corni Fructus based on entropy method combined with analytic hierarchy process and BP neural network[J]. Chinese Traditional and Herbal Drugs,2021,52(22):6816?6824. doi:  10.7501/j.issn.0253-2670.2021.22.006

    QIAN Y J, PI W X, ZHU G F, et al. Optimization of processing technology of wine-steamed Corni Fructus based on entropy method combined with analytic hierarchy process and BP neural network[J]. Chinese Traditional and Herbal Drugs, 2021, 52(22): 6816-6824. doi:  10.7501/j.issn.0253-2670.2021.22.006
    [31] 田春蓮, 丁文. 湖北地黃梓醇超聲波提取及含量測定[J]. 安徽農業科學,2009,37(28):13788?13789,13792. [TIAN C L, DING W. Ultrasonic extraction and content determination of Rehmannia glutinosa in Hubei[J]. Journal of Anhui Agricultural Sciences,2009,37(28):13788?13789,13792. doi:  10.3969/j.issn.0517-6611.2009.28.133

    TIAN C L, DING W. Ultrasonic extraction and content determination of Rehmannia glutinosa in Hubei[J]. Journal of Anhui Agricultural Sciences, 2009, 37(28): 13788-13789, 13792. doi:  10.3969/j.issn.0517-6611.2009.28.133
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  • 收稿日期:  2022-01-03
  • 網絡出版日期:  2022-08-19
  • 刊出日期:  2022-09-23

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